Post-transcriptional gene silencing

  • Date: –16:15
  • Location: Biomedicinskt centrum, BMC C8:321
  • Lecturer: PhD Oleksandr Plashkevych
  • Organiser: Institutionen för cell- och molekylärbiologi
  • Contact person: Oleksandr Plashkevych
  • Docentföreläsning

The Department of Cell and Molecular Biology hereby invite all interested to a docent (associate professorship) lecture in subject Biology with specialization in Molecular Biology.

The lecture is an obligatory teaching test for those applying for admittance as docent (associate professor) and it should be possible for students and others with basic academic education in the relevant field to follow it. The lecture will last for 45 minutes and afterwards the audience may ask questions. The lecture will be given in English.

Abstract: Gene silencing is an attractive strategy to regulate selectively and specifically expression of a certain gene in a cell. Gene silencing can be achieved before or during either transcription or translation of the genetic message. By modifying patogenic gene expression or expression of a gene associated with a disease one can potentially produce therapeutic effect to treat a host of serious illnesses like cancer, neurodegenerative disorders,  infectious diseases etc. In this lecture we will limit ourselves to discussion of different messenger RNA (mRNA) targeting approaches leading to Post-Transcriptional Gene Silencing (PTGS), namely antisense oligonuclotides, RNA interference (RNAi) by non-coding  short interfering RNAs (siRNAs) and microRNAs (miRNA), gene expression regulation by microRNA loss-of-function as well as gene silencing by Rybozymes and DNAzymes.  Major definitions and concepts of these promising biotechnological and therapeutic  approaches will be presented and discussed in light of critical hurdles remain to be overcome for these technologies to become clinically established.

Chairperson: Professor Leif Kirsebom

Representative of the Associate Professorship Board: Professor Monika Schmitz